Cary O Harding Selected Research

Fatigue

1/2018

Pegvaliase for the treatment of phenylketonuria: A pivotal, double-blind randomized discontinuation Phase 3 clinical trial.

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Cary O Harding Research Topics

Disease

37	Phenylketonurias (Phenylketonuria) 06/2024 - 11/2003
10	Trifunctional Protein Deficiency With Myopathy And Neuropathy 03/2024 - 06/2003
7	Inborn Urea Cycle Disorders 01/2019 - 06/2013
5	Liver Diseases (Liver Disease) 10/2023 - 07/2014
5	Tyrosinemias (Tyrosinemia) 09/2022 - 07/2014
5	Inborn Errors Metabolism (Inborn Errors of Metabolism) 11/2020 - 08/2010
3	Inborn Genetic Diseases (Disease, Hereditary) 06/2024 - 01/2004
3	Rhabdomyolysis 03/2024 - 09/2006
3	Body Weight (Weight, Body) 01/2022 - 01/2016
3	Hypersensitivity (Allergy) 01/2020 - 01/2018
3	Metabolic Diseases (Metabolic Disease) 12/2019 - 07/2014
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 03/2024 - 01/2023
2	Malnutrition (Nutritional Deficiencies) 12/2023 - 01/2011
2	Intellectual Disability (Idiocy) 12/2023 - 01/2011
2	Atrophy 12/2016 - 10/2016
2	Hepatocellular Carcinoma (Hepatoma) 09/2014 - 05/2008
2	Hyperammonemia 06/2013 - 07/2003
2	Hypoglycemia (Reactive Hypoglycemia) 07/2011 - 07/2003
2	Ketosis 07/2011 - 07/2003
2	Lethargy 07/2003 - 06/2003
1	Peripheral Nervous System Diseases (PNS Diseases) 03/2024
1	Alopecia (Baldness) 12/2023
1	Movement Disorders (Movement Disorder) 12/2023
1	Hemophilia B (Haemophilia B) 01/2021
1	Fever (Fevers) 01/2021
1	Neurologic Manifestations (Neurological Manifestations) 06/2020
1	Immune Complex Diseases (Immune Complex Disease) 11/2018
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2018
1	Headache (Headaches) 01/2018
1	Cognitive Dysfunction 01/2018
1	Arthralgia (Joint Pain) 01/2018
1	Fatigue 01/2018
1	Anaphylaxis (Anaphylactic Shock) 01/2018
1	Methylmalonic acidemia with homocystinuria 12/2016
1	Methylmalonic acidemia 12/2016
1	Retinal Degeneration 12/2016
1	Disease Progression 12/2016
1	Homocystinuria 12/2016
1	Metabolic Bone Diseases (Osteopenia) 01/2016

Drug/Important Bio-Agent (IBA)

22	Phenylalanine (L-Phenylalanine)FDA Link 06/2024 - 11/2003
17	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA 06/2024 - 11/2003
12	Proteins (Proteins, Gene)FDA Link 12/2023 - 06/2003
11	pegvaliaseIBA 06/2024 - 01/2018
8	Fatty Acids (Saturated Fatty Acids)IBA 03/2024 - 06/2003
6	EnzymesIBA 06/2024 - 07/2014
6	Tyrosine (L-Tyrosine)FDA Link 09/2022 - 07/2014
6	glycerol phenylbutyrateIBA 01/2019 - 06/2013
5	sapropterin (tetrahydrobiopterin)FDA Link 12/2023 - 01/2004
5	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022 - 09/2014
5	3-Hydroxyacyl-CoA DehydrogenaseIBA 05/2012 - 06/2003
4	Amino Acids FDA Link 01/2019 - 05/2008
4	Dietary ProteinsIBA 11/2018 - 01/2007
3	Long-Chain-3-Hydroxyacyl-CoA DehydrogenaseIBA 03/2024 - 09/2005
3	Phenylalanine Ammonia-LyaseIBA 12/2022 - 07/2014
3	fumarylacetoacetase (fumarylacetoacetate hydrolase)IBA 01/2019 - 07/2014
3	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 09/2014
3	AmmoniaIBA 07/2015 - 06/2013
3	Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA 11/2013 - 09/2006
2	Acetaminophen (Paracetamol)FDA LinkGeneric 10/2023 - 01/2021
2	Immunoglobulin E (IgE)IBA 11/2018 - 01/2018
2	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 11/2018 - 07/2014
2	Serotonin (5 Hydroxytryptamine)IBA 01/2018 - 01/2016
2	Biomarkers (Surrogate Marker)IBA 11/2017 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 06/2017 - 09/2014
2	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 12/2016 - 07/2003
2	Retinaldehyde (Retinal)IBA 10/2016 - 09/2005
2	NitrogenIBA 09/2015 - 07/2015
2	Urea (Carbamide)FDA LinkGeneric 07/2015 - 05/2008
2	RNA Splice SitesIBA 09/2014 - 03/2013
2	Glucose (Dextrose)FDA LinkGeneric 11/2013 - 05/2012
2	LipidsIBA 11/2013 - 10/2009
2	Mitochondrial Trifunctional ProteinIBA 05/2012 - 09/2006
2	AcidsIBA 05/2006 - 06/2003
1	KetonesIBA 01/2023
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2021
1	Ammonia-LyasesIBA 11/2018
1	Antigen-Antibody Complex (Immune Complex)IBA 11/2018
1	Phosphocreatine (Neoton)IBA 11/2017
1	Vitamin D FDA LinkGeneric 01/2016
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2016
1	BiopterinsIBA 01/2016
1	Tryptophan (L-Tryptophan)FDA Link 01/2016
1	Glutamine (L-Glutamine)FDA Link 07/2015
1	Antisense OligonucleotidesIBA 09/2014
1	Nucleic AcidsIBA 09/2014
1	OligonucleotidesIBA 09/2014
1	MorpholinosIBA 09/2014
1	mitomycin C-DNA adductIBA 09/2014

Therapy/Procedure

15	Therapeutics 12/2023 - 06/2003
3	Transplantation 10/2023 - 07/2014
2	Nutrition Therapy (Medical Nutrition Therapy) 12/2023 - 09/2023
2	Cell Transplantation 10/2023 - 08/2023
2	Diet Therapy (Therapy, Diet) 10/2009 - 01/2004
1	Protein-Restricted Diet (Diet, Protein Restricted) 12/2023
1	Injections 12/2022
1	Drug Tapering 01/2020
1	Duration of Therapy 01/2020
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2019
1	Liver Transplantation 01/2019
1	Organ Transplantation 01/2019